Overexpression of Catalase in Mitochondria Mitigates Changes in Hippocampal Cytokine Expression Following Simulated Microgravity and Isolation
Isolation on Earth can alter physiology and signaling of organs systems, including the central nervous system. Although not in complete solitude, astronauts operate in an isolated environment during spaceflight. In this study, we determined the effects of isolation and simulated
Selection note: Curated because this 2021 reprint (version printed in journal) from Nature Research specifically covers “Overexpression of Catalase in Mitochondria Mitigates Changes in Hippocampal Cytokine Expression Following Simulated Microgravity and Isolation”; its abstract describes Isolation on Earth can alter physiology and signaling of organs systems, including the central nervous system. Although not in complete solitude, astronauts operate in an… This materially informs GShips human factors and habitability.
Evidence boundary: NTRS lists open full text, but this pass assessed catalog metadata and abstract rather than independently validating the document. Inclusion is contextual discovery support, not automatic evidence for a GShips claim.
Stable record
ntrs-20230002967
Topic
human-factors
Type
Reprint (Version printed in journal)
Publisher
Nature Research
Authors
Linda Rubinstein; Ann-sofie Schreurs; Samantha M. Torres; Sonette Steczina; Moniece G. Lowe; Frederico Kiffer; Antiño R. Allen; April E. Ronca
Year
2021
Editorial state
metadata curated editorial draft
Reviewer
GShips Project editorial synthesis
Official link checked
2026-07-25
Source-supplied abstract
Isolation on Earth can alter physiology and signaling of organs systems, including the central nervous system. Although not in complete solitude, astronauts operate in an isolated environment during spaceflight. In this study, we determined the effects of isolation and simulated microgravity solely or combined, on the inflammatory cytokine milieu of the hippocampus. Adult female wild-type mice underwent simulated microgravity by hindlimb unloading for 30 days in single or social (paired) housing. In hippocampus, simulated microgravity and isolation each regulate a discrete repertoire of cytokines associated with inflammation. Their combined effects are not additive. A model for mitochondrial reactive oxygen species (ROS) quenching via targeted overexpression of the human catalase gene to the mitochondria (MCAT mice), are protected from isolation- and/or simulated microgravity-induced changes in cytokine expression. These findings suggest a key role for mitochondrial ROS signaling in neuroinflammatory responses to spaceflight and prolonged bedrest, isolation, and confinement on Earth.
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NTRS lists open full text, but this pass assessed catalog metadata and abstract rather than independently validating the document. Inclusion is contextual discovery support, not automatic evidence for a GShips claim.
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GShips Project
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Editorial reviewer
GShips Project editorial synthesis
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Last independent review
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Last content edit
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Official source or link verified
2026-07-25
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The maintainer intends to explore a commercial venture based on some GShips work. No entity, outside funding, customer, sponsor, or indexed-organization relationship currently exists.